Li Yang
,
Liu Xuqiang
,
Tan Lili
,
Ren Ling
,
Wan Peng
,
Hao Yongqiang
,
Qu Xinhua
,
Yang Ke
,
Dai Kerong
材料科学技术（英）
doi:10.1016/j.jmst.2016.07.013
Implant-associated infection remains a difficult medical problem in orthopedic surgery. Therefore, the development of multifunctional bone implants for treating infection and regenerating lost bone tissue, which may be a result of infection, is important. In the present study, we report the fabrication of enoxacin-loaded poly (lactic-co-glycolic acid) (PLGA) coating on porous magnesium scaffold (Enox-PLGA-Mg) which combine the favorable properties of magnesium, the antibacterial property and the effect of inhibition of osteoclastic bone resorption of enoxacin. The drug loaded PLGA coating of Mg scaffold enables higher drug loading efficiency (52%-56%) than non-coating enoxacin loaded Mg scaffold (Enox-Mg) (4%-5%). Enox-PLGA-Mg exhibits sustained drug release for more than 14 days, and this controlled release of enoxacin significantly inhibits bacterial adhesion and prevented biofilm formation by Staphylococcus epidermidis (ATCC35984) and Staphylococcus aureus (ATCC25923). Biocompatibility tests with Balb/c mouse embryo fibroblasts (Balb/c 3T3 cells) indicate that PLGA-Mg has better biocompatibility than Mg. Finally, we also demonstrate that Enox-PLGA-Mg extract potently inhibited osteoclast formation in vitro. Therefore, Enox-PLGA-Mg has the potential to be used as a multifunctional controlled drug delivery system bone scaffolds to prevent and/or treat orthopedic peri-implant infections.
关键词:
Porous magnesium scaffold
,
Poly (lactic-co-glycolic acid) (PLGA)
,
Drug delivery system
,
Bactericidal activity
,
Enoxacin
,
Osteolysis
Jin Shujing
,
Ren Ling
,
Yang Ke
材料科学技术（英）
doi:10.1016/j.jmst.2016.06.022
Although being an essential trace element required for human body health, Cu has long been seriously considered toxic when its amount exceeds certain limitation, which significantly limited the wide application of Cu in biomaterials. However, more and more bio-functions and benefits of Cu were found and confirmed, attracting the attention from biomaterials researchers in recent years. People have tried to immobilize Cu into biomaterials by various ways, in order to develop novel bio-functional Cu containing biomaterials with better bio-adaptions, and several different bio-functions of them have been demonstrated. This paper makes a review of the development of novel bio-functional Cu containing biomaterials, and focuses on their unique roles in enhancing bio-adaption of biomedical materials, including antibacterial performance, stimulating angiogenesis, promoting osteogenesis and inhibition of in-stent restenosis, aiming at proposing a prospective development direction for biomedical materials with better bio-adaptions.
关键词:
Biomaterials
,
Cu
,
Antibacterial
,
Angiogenesis
,
Osteogenesis
,
In-stent restenosis
Wan Peng
,
Tan Lili
,
Yang Ke
材料科学技术（英）
doi:10.1016/j.jmst.2016.05.003
Magnesium (Mg) and its alloys as a novel kind of biodegradable material have attracted much fundamental research and valuable exploration to develop its clinical application. Mg alloys degrade too fast at the early stage after implantation, thus commonly leading to some problems such as osteolysis, early fast mechanical loss, hydric bubble aggregation, gap formation between the implants and the tissue. Surface modification is one of the effective methods to control the degradation property of Mg alloys to adapt to the need of organism. Some coatings with bioactive elements have been developed, especially for the micro-arc oxidation coating, which has high adhesion strength and can be added with Ca, P, and Sr elements. Chemical deposition coating including bio-mimetic deposition coating, electro-deposition coating and chemical conversion coating can provide good anticorrosion property as well as better bioactivity with higher Ca and P content in the coating. From the biodegradation study, it can be seen that surface coating protected the Mg alloys at the early stage providing the Mg alloy substrate with lower degradation rate. The biocompatibility study showed that the surface modification could provide the cell and tissue stable and weak alkaline surface micro-environment adapting to the cell adhesion and tissue growth. The surface modification also decreased the mechanical loss at the early stage adapting to the load-bearing requirement at this stage. From the interface strength between Mg alloys implants and the surrounding tissue study, it can be seen that the surface modification improved the bio-adhesion of Mg alloys with the surrounding tissue, which is believed to be contributed to the tissue adaptability of the surface modification. Therefore, the surface modification adapts the biodegradable magnesium alloys to the need of biodegradation, biocompatibility and mechanical loss property. For the different clinical application, different surface modification methods can be provided to adapt to the clinical requirements for the Mg alloy implants.
关键词:
Bio-adaptability
,
Coating
,
Biodegradable
,
Magnesium alloys
,
Orthopedic implants
戢景文
,
魏全金
,
张国福
,
赖祖涵
,
陈廷国
金属学报
研究了F? P—N合金加?对Snoek—Ke-Koster(SKK)峰的影响,发现与合金含La,P的原子浓度比(C_(La)/C_p)有关:对于C_(La)/C_p较大(例如4.56和2.6)的合金,La有明显增强SKK阻?效应:对于C_(La)/C_p=0.27的P过饱和合金,La对SKK峰无明显影响。
关键词:
内耗
,
Snoek-Ke-Koster peak
,
Fe-P-La-N alloy
Canying CAI
,
Qibin YANG
,
Hongrong LIU
材料科学技术（英）
Assuming that the wave function , the Schrodinger equation can be written as . Neglecting the last two terms, an analytical expression of electron dynamical diffraction was derived by Qibin YANG et al. In this paper, the analytical expression is modified by further considering the second-order differential term . When the accelerating voltage is not very high, or the sample is not very thin, the reciprocal vector ɡ is large, the modification of the second-order differential is necessary; otherwise it can be neglected.
关键词:
Electron dynamical diffraction
,
null
JI Jingwen LAI Zuhan WU Yuqin ZHANG Guofu Northeast University of Technology
,
Shenyang
,
ChinaLI Guangyi Institute of Metal Research
,
Academia Sinica
,
Shenyang
,
China
金属学报(英文版)
The strong effect of rare earth(RE)on medium-temperature internal friction(IF)of commercially pure iron is closely related to the heat treatment.The RE added into iron has an alloying effect.The Snoek-Ke-Kster(briefly SKK)peak lower as the aging temperature in- creases from 150℃ to 450℃,but it still exists even aged at 600℃.However,the SKK peak temperature T_p does not simply falls as the ascending of aging temperature,it rises again at 600℃ aging.
关键词:
internal friction
,
null
,
null
张淑芳
,
方亮
,
付光宗
,
董建新
,
陈勇
材料导报
研究了导热硅脂(KE3493)涂层对水下密闭环境下应用的LED灯散热情况的影响,结果表明,LED系统的集成电路板上加入导热涂层能提高LED系统的散热效率,研究结果为导热涂层应用于LED散热系统提供了参考数据.
关键词:
导热涂层
,
散热性能
,
LED
,
硅脂
Chinese Physics Letters
Dynamic Monte Carlo simulation is used to explore the B isotope sputtering during 1 ke V Kr ion irradiation. It is found that at both zero and high fluences the light isotope is preferentially ejected in the near-normal direction; meanwhile, there is a low fluence (1.4 x 10(15) ions/cm2), at which the isotope fractionation is independent of the emission angle in the nearly whole angular range.
关键词:
simulation
中国腐蚀与防护学报
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